Comparative assessment of LDL-C and VLDL-C estimation in familial combined hyperlipidemia using Sampson’s, Martin’s and Friedewald’s equations

Abstract Background Sampson et al. developed a novel method to estimate very low-density lipoprotein cholesterol (VLDL-C) and (LDL-C) in the setting of hypertriglyceridemia. Familial Combined Hyperlipidemia (FCHL) is common primary dyslipidemia which composition interferes with LDL-C estimation. This study aimed evaluate performance using this new (LDL-S) compared estimated by Friedewald’s Martin eq. (LDL-F, LDL-M) FCHL. Methods Data were collected from 340 subjects confirmed Concordance for VLDL-C measured ultracentrifugation these measures Sampson’s, Martin’s equations was performed correlation coefficients, root mean squared error (RMSE) bias. Also, concordance misclassified metrics according (< 70 < 100 mg/dL) Apo B 80 65 thresholds assessed. Results Sampson’s equation more accurate (RMSE 11.21 mg/dL; R 2 = 0.88) 13.15 0.875) 13.7 0.869). When assessing LDL-C, had highest lowest RMSE other 19.99 0.840). Comparing strength across triglyceride levels, showed consistently improved correlations formulas increasing triglycerides FCHL phenotype mixed dyslipidemia. also treatment goals. Conclusions In FCHL, estimation formula higher lipid targets assessed obtained equations. Implementation could improve monitoring